gerStein group at yaLe addS new dimenSion to protein interaCtion networKS

The result is termed the structural interaction network (SIN), which consists of 873 proteins and1269 interactions, 438 which were found to be mutually exclusive. In initial analyses of the SIN, notable properties include a maximum of 14 interaction partners per “hub” protein, in contrast to earlier interactome studies reporting much higher ranges. The approach also distinguishes between “multi-interface” hubs that involve simultaneously possible interactions and “singlish-interface” hubs with mutually exclusive interactions, and shows that the former are more likely to be essential, co-expressed, and show lower evolutionary rate (dN/dS). The SIN dataset and updates can be found at http://sin.gersteinlab.org.